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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

In all tissues (muscles, organs especially the liver ) mainly adenosylcobalamin is found In the blood and spinal cord methylcobalamin and hydroxocobalamin are found in equal measure (10) In the cells both adenosylcobalamin and methylcobalamin are required, which can easily be transformed into each other Vitamin B12 Active Ingredients in Supplements Previously, in vitamin B12 supplements synthetic cyanocobalamin and hydroxocobalamin were mainly used in B12 injections

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In further embodiments, the invention encompasses a method of treating Parkinson and related neurological diseases by administering a therapeutically effective amount of one or more cations chosen from Tables 1, 2, 3a, and 3b